Α-AMANITINCURRENTLY UNAVAILABLE
Alpha-Amanitin
CAS: 23109-05-9
Molecular Formula: C39H54N10O14S
Α-AMANITINCURRENTLY UNAVAILABLE - Names and Identifiers
Α-AMANITINCURRENTLY UNAVAILABLE - Physico-chemical Properties
| Molecular Formula | C39H54N10O14S |
| Molar Mass | 918.98 |
| Density | 1.1626 (rough estimate) |
| Melting Point | 254-255°C(lit.) |
| Boling Point | 1622.2±65.0 °C(Predicted) |
| Specific Rotation(α) | D20 +191° |
| Solubility | H2O: 1.0mg/mL |
| Appearance | powder |
| Color | white to light yellow |
| Merck | 13,370 |
| BRN | 1071138 |
| pKa | 9.63±0.70(Predicted) |
| Storage Condition | −20°C |
| Refractive Index | 1.7400 (estimate) |
Α-AMANITINCURRENTLY UNAVAILABLE - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects R26/28 - Very toxic by inhalation and if swallowed. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | BD6195000 |
| FLUKA BRAND F CODES | 8-10-18-21 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland) |
Α-AMANITINCURRENTLY UNAVAILABLE - Reference Information
| Introduction | mushroom poison amentum, also known as "lethal amsome mushroom", has been used for murder and has a long history Suicide, it can be traced back to ancient Rome. The fungus, known by the scientific name Amanita phalloides, produces one of the most toxic toxins in the world: Alpha-amantins. Now researchers are keen to synthesize the toxin, which at first glance may seem like a Rancy, but because research has shown that it may help treat cancer. The scientists reported in the Journal of the American Chemical Society their process of overcoming obstacles in the synthesis of the deadly compound of this poisonous goose cream. |
| physical and chemical activity | the peptides contained in highly toxic amentum are soluble in water, chemically stable, resistant to high temperature and acid-base, the process of cooking does not inactivate these toxins. After entering the human body, the peptide can be absorbed by the digestive tract, enter the liver cells through the blood circulation, and combine with RNA polymerase to inhibit the synthesis of messenger RNA, thereby blocking the metabolism of cells. After dissociating with the polymerase, the amentum toxin peptide is discharged into the bile, flows into the intestine with the bile, is absorbed in the small intestine, passes through the blood circulation, and is reabsorbed by the liver, this results in the formation of enterohepatic circulation, which repeatedly causes damage to the liver. |
| category | toxic substances |
| toxicity grade | highly toxic |
| Acute toxicity | intraperitoneal-mouse LD50:0.1 mg/kg |
| flammability hazard characteristics | flammability; Toxic nitrogen oxide and sulfur oxide fumes from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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CAS: 23109-05-9
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CAS: 23109-05-9
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